Cryo-ET of IgG bivalent binding on SARS-CoV-2 provides structural basis for antibody avidity
Published:
Journal: BioRxiv
Method
Cryo-ET
Summary
They incubated two potent IgG antibodies with SARS-CoV2 virion and found 1) both antibodies can dimerize the spike trimers; 2) one antibody crosslink the spike trimers into rings on the virus membrane, while the other antibody crosslink the spike trimers into lines.