Published in Science Advances, 2025
Cryo‑EM structures of HERV‑K envelope in both pre‑ and post‑fusion conformations complexed with novel monoclonal antibodies. Read the press release
Recommended citation: Jeremy Shek et al. ,Human endogenous retrovirus K (HERV-K) envelope structures in pre- and postfusion by cryo-EM.Sci. Adv.11,eady8168(2025).DOI:10.1126/sciadv.ady8168
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Published in Nature, 2025
This study reveals the structural heterogeneity of mammalian axonemes using cryo-EM, offering insights into tissue-specific ciliary architecture.
Recommended citation: Leung MR, Chen Sun, Zeng J, Anderson JR, Niu Q, Huang W, Noteborn WEM, Brown A, Zeev-Ben-Mordehai T, Zhang R. (2025). "Structural diversity of axonemes across mammalian motile cilia." Nature. 637(8048):1170–1177. https://doi.org/10.1038/s41586-024-08337-5
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Published in Biomolecules, 2024
Recommended citation: Chen Sun, Pengwei Huang, Xueyong Xu, Frank S. Vago, Kunpeng Li, Thomas Klose, Xi Jason Jiang, and Wen Jiang. (2024). "The 2.6 Å Structure of a Tulane Virus Variant with Minor Mutations Leading to Receptor Change." Biomolecules. 14, no. 1: 119.
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Published in Scientific Reports, 2022
A user-friendly web interface for automatically determining helical parameters from an initial model in real space.
Recommended citation: Chen Sun, Brenda Gonzalez, Wen Jiang. (2022). "Helical Indexing in Real Space." Scientific Reports. 12, 8162.
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Published in Progress in Biophysics and Molecular Biology, 2021
This paper introduces JSPR, a cryo-EM refinement tool that enhances single particle resolution through improved real-space alignment and classification strategies.
Recommended citation: Chen Sun, Brenda Gonzalez, Frank S. Vago, and Wen Jiang. (2021). "High resolution single particle Cryo-EM refinement using JSPR." Progress in Biophysics and Molecular Biology. 160: 37–42.
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Published in Nature Communications, 2021
Recommended citation: Runrun Wu, Jeremy W. Bakelar, Karl Lundquist, Zijian Zhang, Katie M. Kuo, David Ryoo, Yui Tik Pang, Chen Sun, Tommi White, Thomas Klose, Wen Jiang, James C. Gumbart and Nicholas Noinaj. (2021). "Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM." Nature Communications. 12, 7137.
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Published in Biomolecules, 2020
This study reports the cryo-EM structure of Thermotoga maritima encapsulin loaded with a heterologous protein complex, providing insight into capsid architecture and protein cargo encapsulation.
Recommended citation: Xiong, Xiansong*, Chen Sun*, Frank S. Vago, Thomas Klose, Jiankang Zhu, and Wen Jiang. (2020). "Cryo-EM Structure of Heterologous Protein Complex Loaded Thermotoga Maritima Encapsulin Capsid." Biomolecules. 10(9): 1342.
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Published in Scientific Reports, 2020
Recommended citation: Irimia-Dominguez, Jose, Chen Sun, Kunpeng Li, Barry B. Muhoberac, Grace I. Hallinan, Holly J. Garringer, Bernardino Ghetti, Wen Jiang, and Ruben Vidal. (2020). "Cryo-EM structures and functional characterization of homo-and heteropolymers of human ferritin variants." Scientific Reports. 10, no. 1.
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Published in Journal of Structural Biology, 2019
In this study, we evaluated the feasibility of using a single position on the Volta Phase Plate (VPP) and examined its impact on image quality and phase shift distribution. Two cryo-EM datasets were collected—one with phase shifts ranging from 0–180°, and another extending to 0–360°. Both datasets yielded high-resolution reconstructions of apoferritin. Our results demonstrate that images with large phase shifts remain suitable for high-resolution structure determination, highlighting the robustness and flexibility of VPP imaging strategies.
Recommended citation: Kunpeng Li, Chen Sun, Thomas Klose, Frank S. Vago, Jose Irimia-Dominguez, Ruben Vidal, Wen Jiang. (2019). "Sub-3 Å Apoferritin Structure Determined With Full Range of Phase Shifts Using A Single Position Of Volta Phase Plate." Journal of Structural Biology. 206(2), pp. 225–232.
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Published in ACS Nano, 2018
This study presents a bioengineered S60 nanoparticle derived from Norovirus as a versatile vaccine platform capable of displaying various antigens.
Recommended citation: Xia M, Huang P, Sun C, Han L, Vago FS, Li K, Zhong W, Jiang W, Klassen JS, Jiang X, Tan M. (2018). "Bioengineered Norovirus S60 Nanoparticles as a Multifunctional Vaccine Platform." ACS Nano. 12(11):10665–10682. https://doi.org/10.1021/acsnano.8b02776
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